From solid state to in vitro anticancer activity of copper(ii) compounds with electronically-modulated NNO Schiff base ligands

Author:

Rigamonti Luca1234ORCID,Reginato Francesco1234,Ferrari Erika1234ORCID,Pigani Laura1234ORCID,Gigli Lara564ORCID,Demitri Nicola564ORCID,Kopel Pavel7891011ORCID,Tesarova Barbora12131411,Heger Zbynek1213141115ORCID

Affiliation:

1. Dipartimento di Scienze Chimiche e Geologiche

2. Università degli Studi di Modena e Reggio Emilia

3. 41125 Modena

4. Italy

5. Elettra Synchrotron Trieste

6. 34149 Basovizza

7. Department of Inorganic Chemistry

8. Faculty of Science

9. Palacky University

10. Olomouc

11. Czech Republic

12. Department of Chemistry and Biochemistry

13. Mendel University

14. Brno

15. Central European Institute of Technology

Abstract

The electron withdrawing nitro group enhances the in vitro cytotoxicity of copper(ii) complexes bearing tridentate NNO Schiff base ligands.

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Università Degli Studi di Modena e Reggio Emila

Elettra-Sincrotrone Trieste

Grantová Agentura České Republiky

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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3. W. Kaim , B.Schwederski and A.Klein , Bioinorganic chemistry: inorganic elements in the chemistry of life: an introduction and guide , Wiley , Chichester, West Sussex, United Kingdom , 2nd edn, 2013

4. The side effects of platinum-based chemotherapy drugs: a review for chemists

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