A degradable nanogel drug carrier crosslinked with three-oligonucleotide hybrids for two-way drug release in mild and high hyperthermia treatment

Abstract

Three-segment oligonucleotide hybrids introduced as crosslinkers to a PNIPA–AAc nanonetwork can be specifically transformed and degraded. Architecture of presented carrier helped to achieve enhanced drug loading and tunable and degradable gel properties, and to control release of the drug.