Base- and metal-free visible-light driven site-selective α-C(sp<sup>3</sup>)–H functionalization reaction of glycine derivatives with hydroxamic acid derivatives-Reference-Cited by-同舟云学术

Base- and metal-free visible-light driven site-selective α-C(sp³)–H functionalization reaction of glycine derivatives with hydroxamic acid derivatives

Published:2024 Issue:11 Volume:11 Page:3119-3123
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

He Shiyun¹,Fan Hongying¹,Zhang Xue¹,Ye Meiling¹,Chen Jian¹,Hou Jinyu¹,Huang Tianle¹,Guo Li¹,Lv Guanghui²,Wu Yong¹^ORCID

Affiliation:

1. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Department of Medicinal Chemistry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, No. 17 Southern Renmin Road, Chengdu, Sichuan 610041, People's Republic of China

2. Department of Pharmacy, Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China

Abstract

A visible-light-mediated radical–radical cross-coupling reaction between hydroxamic acid and N-phenyl glycine derivatives under base and metal free conditions is reported. A series of unnatural amino acids and peptides were obtained in good to excellent yields with good chemo-selectivity.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D4QO00425F

Reference30 articles.

1. Therapeutic peptides

2. The Medicinal Chemistry of Peptides

3. Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

4. Designing peptide receptor agonists and antagonists

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