Synthesis, proteolytic stability, and in vitro evaluation of DOTA conjugated p160 peptide based radioconjugates: [177Lu]Lu–DOTA

Synthesis, proteolytic stability, and in vitro evaluation of DOTA conjugated p160 peptide based radioconjugates: [177Lu]Lu–DOTA–p160

Published:2021 Issue:45 Volume:19 Page:9849-9854
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Kaur Jasleen¹²^ORCID,Arroub Karim³,Drzezga Alexander²,Schomäcker Klaus²,Mathur Sanjay³^ORCID

Affiliation:

1. Amity Institute of Virology and Immunology, Sector-125, Amity University, Noida, 201313, Uttar Pradesh, India

2. University Clinic of Cologne, Clinic of Nuclear Medicine, Cologne, Germany

3. Institute of Inorganic Chemistry, University of Cologne, Cologne, Germany

Abstract

Synthesis, spectroscopic characterization, and in vitro biological evaluation of Lu-177 radiolabeled DOTA conjugated p160 peptide derivatives: potential candidates for breast tumor imaging and therapy.

Funder

Universität zu Köln

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01812D

Reference25 articles.

1. Supramolecular Photothermal Nanomedicine Mediated Distant Tumor Inhibition via PD-1 and TIM-3 Blockage

2. New Developments in Peptide Receptor Radionuclide Therapy

3. Radiolabeled Peptides: Valuable Tools for the Detection and Treatment of Cancer

4. Peptide-Based 68Ga-PET Radiotracer for Imaging PD-L1 Expression in Cancer

5. Advances in Fmoc solid‐phase peptide synthesis

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