Target-controlled in situ formation of G-quadruplex DNAzyme for a sensitive visual assay of telomerase activity-Reference-Cited by-同舟云学术

Target-controlled in situ formation of G-quadruplex DNAzyme for a sensitive visual assay of telomerase activity

Published:2019 Issue:20 Volume:144 Page:5959-5964
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Wang Yaocai¹²³⁴⁵,Yang Luzhu¹²³⁴⁵,Wang Yanjun¹²³⁴⁵,Liu Wei¹²³⁴⁵^ORCID,Li Baoxin¹²³⁴⁵^ORCID,Jin Yan¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Applied Surface and Colloid Chemistry

2. Ministry of Education

3. Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province

4. School of Chemistry and Chemical Engineering

5. Shaanxi Normal University

Abstract

A sensitive visual assay was developed for detecting telomerase activity based on the telomerase-controlled in situ formation of G-quadruplex-hemin DNAzyme. The telomerase activity of 5 HeLa cells per μL was visually detected in human serum.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/AN/C9AN01271K

Reference25 articles.

1. Telomerase and cancer therapeutics

2. Cancer biomarker detection: recent achievements and challenges

3. PCR-free and label-free fluorescent detection of telomerase activity at single-cell level based on triple amplification

4. Nanoparticle-Aided Amplification of Fluorescence Polarization for Ultrasensitively Monitoring Activity of Telomerase

5. In situ fluorescence activation of DNA–silver nanoclusters as a label-free and general strategy for cell nucleus imaging

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