Coordination of signaling and tissue mechanics during morphogenesis of murine intestinal villi: a role for mitotic cell rounding

Author:

Freddo Andrew M.1234,Shoffner Suzanne K.5234,Shao Yue6734,Taniguchi Kenichiro1234,Grosse Ann S.894,Guysinger Margaux N.1234,Wang Sha1234,Rudraraju Shiva6734,Margolis Benjamin10234,Garikipati Krishna673411,Schnell Santiago523412ORCID,Gumucio Deborah L.1234

Affiliation:

1. Department of Cell and Developmental Biology

2. University of Michigan Medical School

3. Ann Arbor

4. USA

5. Department of Molecular and Integrative Physiology

6. Department of Mechanical Engineering

7. University of Michigan

8. Charles River Laboratories

9. Wilmington

10. Department of Internal Medicine

11. Department of Mathematics

12. Department of Computational Medicine and Bioinformatics

Abstract

Murine intestinal villi are rapidly demarcated by patterned intraepithelial forces that are induced by mesenchymal cell clusters and accelerated by cell division.

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

Publisher

Oxford University Press (OUP)

Subject

Biochemistry,Biophysics

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