Enzymatic reduction of halogenated aryl ketones in an aqueous micellar solution with enhanced catalytic performance

Author:

Liu Yunting12,Yan Jiajing1,Yuan Quan1,Ma Li1ORCID,Zhou Liya1,He Ying1,Liu Guanhua1ORCID,Yue Xiaoyang1,Jiang Yanjun12ORCID

Affiliation:

1. School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300401, China

2. National-Local Joint Engineering Laboratory for Energy Conservation in Chemical Process Integration and Resources Utilization, Hebei University of Technology, Tianjin 300401, China

Abstract

The synthesis of enantiopure chiral halogenated aryl alcohols by ketoreductases was conducted in an aqueous micellar solution formed by TPGS-750-M, achieving remarkable yields and enantioselectivities under high concentration.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Natural Science Foundation of Hebei Province

Hebei Province Science and Technology Support Program

Department of Education of Hebei Province

Publisher

Royal Society of Chemistry (RSC)

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