Facile synthesis of rapamycin-peptide conjugates as mTOR and Akt inhibitors-Reference-Cited by-同舟云学术

Facile synthesis of rapamycin-peptide conjugates as mTOR and Akt inhibitors

Published:2021 Issue:19 Volume:19 Page:4352-4358
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Singh Shalini¹²³⁴,Ali Rafat¹²³⁴,Miyan Javed⁵²³⁴,Singh Varsha⁵²³⁴,Meena Sanjeev⁵²³⁴,Hasanain Mohammad⁵²³⁴,Bhadauria Smrati⁵²³⁴⁶,Datta Dipak⁵²³⁴⁶,Sarkar Jayanta⁵²³⁴⁶,Haq Wahajul¹²³⁴⁶^ORCID

Affiliation:

1. Medicinal and Process Chemistry Division

2. CSIR–Central Drug Research Institute

3. Lucknow

4. India

5. Division of Cancer Biology

6. Academy of Scientific and Innovative Research

Abstract

An efficient methodology for the synthesis of rapamycin peptide conjugates was developed. Some of these conjugates were found to inhibit the kinase activity of both mTOR and Akt.

Funder

Council of Scientific and Industrial Research, India

University Grants Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB00132A

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