Identification of inhibitors of UDP-galactopyranose mutase via combinatorial in situ screening-Reference-Cited by-同舟云学术

Identification of inhibitors of UDP-galactopyranose mutase via combinatorial in situ screening

Published:2021 Issue:8 Volume:19 Page:1818-1826
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Fu Jian¹²³⁴⁵^ORCID,Fu Huixiao⁵⁶⁷⁸,Xia Yufen¹²³⁴,N'Go Inès⁵⁶⁷⁸,Cao Jun⁵⁶⁷⁸,Pan Weidong⁹¹⁰⁴,Vincent Stéphane P.⁵⁶⁷⁸^ORCID

Affiliation:

1. College of Pharmacy

2. Guizhou University of Traditional Chinese Medicine

3. Guiyang

4. China

5. Department of Chemistry

6. University of Namur

7. 5000 Namur

8. Belgium

9. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences

10. Guiyang 550002

Abstract

An in situ screening assay for UDP-galactopyranose mutase (UGM, an essential enzyme of M. tuberculosis cell wall biosynthesis) has been developed to discover novel UGM inhibitors.

Funder

National Natural Science Foundation of China

Guizhou Science and Technology Department

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB00138H

Reference55 articles.

1. Global tuberculosis report 2020 , World Health Organization , Geneva , 2020

2. Is the mycobacterial cell wall a hopeless drug target for latent tuberculosis?

3. The bacterial cell wall as a source of antibacterial targets

4. Mycobacterial cell wall: Structure and role in natural resistance to antibiotics

5. The Cell-Wall Core of Mycobacterium tuberculosis in the Context of Drug Discovery.

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