A multi-step continuous flow synthesis of the cystic fibrosis medicine ivacaftor-Reference-Cited by-同舟云学术

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A multi-step continuous flow synthesis of the cystic fibrosis medicine ivacaftor

Published:2018 Issue:4 Volume:3 Page:520-526
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Vasudevan N.¹²³⁴,Sharma Mrityunjay K.⁵²³⁴,Reddy D. Srinivasa¹²³⁴^ORCID,Kulkarni Amol A.⁵²³⁴^ORCID

Affiliation:

1. Division of Organic Chemistry

2. CSIR-National Chemical Laboratory

3. Pune – 411008

4. India

5. Chemical Engineering and Process Development Division

Abstract

A continuous flow ozonolysis method combined with a multi-step flow sequence is developed for the synthesis of the drug ivacaftor for the first time.

Funder

University Grants Commission

Council for Scientific and Industrial Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RE/C8RE00025E

Reference55 articles.

1. On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system

2. Synthesis of Long Oxahelicenes by Polycyclization in a Flow Reactor

3. Stereoselective Catalytic Synthesis of Active Pharmaceutical Ingredients in Homemade 3D-Printed Mesoreactors

4. Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts

5. Contribution of microreactor technology and flow chemistry to the development of green and sustainable synthesis

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