Divalent metal ions control activity and inhibition of protein kinases-Reference-Cited by-同舟云学术

Divalent metal ions control activity and inhibition of protein kinases

Published:2017 Issue:11 Volume:9 Page:1576-1584
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Knape Matthias J.¹²³^ORCID,Ballez Mike¹²³,Burghardt Nicole C.¹²³,Zimmermann Bastian⁴²³^ORCID,Bertinetti Daniela¹²³^ORCID,Kornev Alexandr P.⁵⁶⁷^ORCID,Herberg Friedrich W.¹²³^ORCID

Affiliation:

1. Department of Biochemistry, University of Kassel

2. 34132 Kassel

3. Germany

4. Biaffin GmbH and Co KG

5. Department of Pharmacology, University of California, San Diego

6. La Jolla

7. USA

Abstract

Metals like Zn²⁺ and Mn²⁺ can assist in the catalytic cycle of a protein kinase by facilitating substrate binding and phosphotransfer, however, in contrast to Mg²⁺ they also hamper product release.

Funder

Michael J. Fox Foundation for Parkinson's Research

Deutsche Forschungsgemeinschaft

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2017/MT/C7MT00204A

Reference43 articles.

1. Cellular transport and homeostasis of essential and nonessential metals

2. Generation and functions of second messengers microdomains