One-pot method for the synthesis of 1-aryl-2-aminoalkanol derivatives from the corresponding amides or nitriles-Reference-Cited by-同舟云学术

One-pot method for the synthesis of 1-aryl-2-aminoalkanol derivatives from the corresponding amides or nitriles

Published:2020 Issue:42 Volume:10 Page:25029-25045
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Otevrel Jan¹²³⁴⁵^ORCID,Svestka David¹²³⁴⁵,Bobal Pavel¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemical Drugs

2. Faculty of Pharmacy

3. Masaryk University

4. 612 42 Brno

5. Czech Republic

Abstract

A one-pot method for β-amino alcohol synthesis based on α-hydroxylation and subsequent amide or nitrile functional group reduction has been identified and examined.

Funder

Ministerstvo Školství, Mládeže a Tělovýchovy

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA04359A

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3. M.Hyneck , J.Dent , J. B.Hook , E. J.Ariens and D. S.Davies , in Chirality in Drug Design and Synthesis , ed. C. Brown , Academic Press , San Diego , 1 st edn, 2013 , pp. 1–51

4. 1,2-Amino Alcohols and Their Heterocyclic Derivatives as Chiral Auxiliaries in Asymmetric Synthesis

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