Synthesis of biurets via TMSNCO addition to 1-aminosugars: application in the de novo synthesis of dC oxidation products
Author:
Affiliation:
1. Organic Chemistry Laboratory
2. Department of Chemistry
3. National and Kapodistrian University of Athens
4. Athens
5. Greece
Abstract
We report an efficient one-step transformation of amines to biurets that has been applied to a number of 1-aminosugars and has led to the de novo synthesis of dfBU and dpBU, two known oxidatively produced lesions of 2′-deoxycytidine.
Funder
European Social Fund
European Cooperation in Science and Technology
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/OB/C8OB02810A
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1. Discovery of a nanomolar inhibitor of lung adenocarcinoma in vitro
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3. Formation of 5-azauridine, ribosyl N-formylbiuret, ribosyl biuret, and their 5'-phosphates in Escherichia coli culture from 5-azauracil
4. Oxidative Damage to DNA Constituents by Iron-mediated Fenton Reactions
5. Hydroxyl-Radical-Induced Decomposition of 2‘-Deoxycytidine in Aerated Aqueous Solutions
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