PROTACs suppression of CDK4/6, crucial kinases for cell cycle regulation in cancer-Reference-Cited by-同舟云学术

PROTACs suppression of CDK4/6, crucial kinases for cell cycle regulation in cancer

Published:2019 Issue:18 Volume:55 Page:2704-2707
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Zhao Bosheng¹²³⁴^ORCID,Burgess Kevin¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Texas A & M University

3. College Station

4. USA

Abstract

PROTACs based on two selective, FDA approved, CDK4/6 inhibitors were formed. These PROTACs at nanomolar concentrations deplete CDK4/6.

Funder

U.S. Department of Defense

National Institutes of Health

Welch Foundation

National Science Foundation

Cancer Prevention and Research Institute of Texas

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C9CC00163H

Reference19 articles.

1. CDK4/6 inhibition in breast cancer: current practice and future directions

2. CDK4/6 Inhibition in Cancer: Beyond Cell Cycle Arrest

3. Treating cancer with selective CDK4/6 inhibitors

4. CDK4/6 Inhibitors: The Mechanism of Action May Not Be as Simple as Once Thought

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