Molecular recognition-driven supramolecular nanoassembly of a hydrophobic uracil prodrug and hydrophilic cytarabine for precise combination treatment of solid and non-solid tumors-Reference-Cited by-同舟云学术

Molecular recognition-driven supramolecular nanoassembly of a hydrophobic uracil prodrug and hydrophilic cytarabine for precise combination treatment of solid and non-solid tumors

Published:2022 Issue:2 Volume:7 Page:235-245
ISSN:2055-6756
Container-title:Nanoscale Horizons
language:en
Short-container-title:Nanoscale Horiz.

Author:

Li Chang¹,Wang Qiu¹,Li Dan¹,Liu Yubo¹,Hu Baichun²^ORCID,Feng Yao²,Zhang Haotian³,He Zhonggui¹^ORCID,Luo Cong¹,Sun Jin¹^ORCID

Affiliation:

1. Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China

2. Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China

3. School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, 110016, P. R. China

Abstract

The reduction sensitive supramolecular nanoassembly was based on U-SS-DOX and Ara-C specific molecular recognition. The drug release in the supramolecular nanoassembly was triggered and controlled in tumor cells with low pH and excessive GSH.

Funder

Liaoning Revitalization Talents Program

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NH/D1NH00590A

Reference29 articles.

1. Self-Assembling Monomeric Nucleoside Molecular Nanoparticles Loaded with 5-FU Enhancing Therapeutic Efficacy against Oral Cancer

2. Prodrug-based nanoparticulate drug delivery strategies for cancer therapy