Evaluation of the binding mode of a cytotoxic dinuclear nickel complex to two neighboring phosphates of the DNA backbone-Reference-Cited by-同舟云学术

Evaluation of the binding mode of a cytotoxic dinuclear nickel complex to two neighboring phosphates of the DNA backbone

Published:2022 Issue:7 Volume:51 Page:2863-2875
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Simon Jasmin¹,Horstmann née Gruschka Claudia¹,Mix Andreas²,Stammler Anja¹,Oldengott Jan¹,Bögge Hartmut¹,Glaser Thorsten¹^ORCID

Affiliation:

1. Lehrstuhl für Anorganische Chemie I, Fakultät für Chemie, Universität Bielefeld, Universitätsstrasse 25, D-33615 Bielefeld, Germany

2. Lehrstuhl für Anorganische Chemie und Strukturchemie, Fakultät für Chemie, Universität Bielefeld, Universitätsstrasse 25, D-33615 Bielefeld, Germany

Abstract

The binding of phosphate diesters to cytotoxic NiII complexes has been studied by single-crystal X-ray crystallography, NMR titration, and computational chemistry to evaluate the binding mode of these complexes to the phosphate backbone of DNA.

Funder

Deutsche Forschungsgemeinschaft

Universität Bielefeld

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/DT/D1DT03813C

Reference51 articles.

1. Cisplatin: mode of cytotoxic action and molecular basis of resistance

2. Structure, Recognition, and Processing of Cisplatin−DNA Adducts