A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A-Reference-Cited by-同舟云学术

A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A

Published:2019 Issue:35 Volume:17 Page:8094-8105
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Doherty William¹²³⁴^ORCID,Dürr Eva-Maria¹²³⁴^ORCID,Baddock Hannah T.⁵⁶⁷⁸⁹,Lee Sook Y.⁵⁶⁷⁸⁹,McHugh Peter J.⁵⁶⁷⁸⁹,Brown Tom¹⁰⁷¹¹¹²^ORCID,Senge Mathias O.¹³¹⁴¹⁵²¹⁶^ORCID,Scanlan Eoin M.¹²³⁴,McGouran Joanna F.¹²³⁴^ORCID

Affiliation:

1. School of Chemistry and Trinity Biomedical Sciences Institute

2. Trinity College Dublin

3. Dublin 2

4. Ireland

5. Department of Oncology

6. MRC Weatherall Institute of Molecular Medicine

7. University of Oxford

8. John Radcliffe Hospital

9. Oxford OX3 9DS

10. Department of Chemistry

11. Oxford OX1 3TA

12. UK

13. Molecular Medicine

14. Trinity Translational Medicine Institute

15. Trinity Centre for Health Sciences

16. The University of Dublin

Abstract

Modified thymidine incorporating zinc-binding pharmacophores offers a novel approach for inhibitor development of SNM1A using rationally designed nucleoside derived inhibitors.

Funder

Wellcome Trust

Science Foundation Ireland

Cancer Research UK

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01133A

Reference33 articles.

1. RPA activates the XPF ‐ ERCC 1 endonuclease to initiate processing of DNA interstrand crosslinks