Functionalized cyclopentenes through a tandem NHC-catalyzed dynamic kinetic resolution and ambient temperature decarboxylation: mechanistic insight and synthetic application-Reference-Cited by-同舟云学术

Functionalized cyclopentenes through a tandem NHC-catalyzed dynamic kinetic resolution and ambient temperature decarboxylation: mechanistic insight and synthetic application

Published:2015 Issue:13 Volume:51 Page:2690-2693
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Cohen Daniel T.¹²³⁴⁵,Johnston Ryne C.¹⁶⁷⁸,Rosson Nicholas T.¹⁶⁷⁸,Cheong Paul Ha-Yeon¹⁶⁷⁸,Scheidt Karl A.¹²³⁴⁵

Affiliation:

1. Department of Chemistry

2. Center for Molecular Innovation and Drug Discovery

3. Chemistry of Life Processes Institute

4. Northwestern University

5. Evanston

6. Oregon State University

7. Corvallis

8. USA

Abstract

An unusual room temperature β-lactone decarboxylation facilitated a five-step enantioselective formal synthesis of the cyclopentane core of an estrogen receptor β-agonist.

Funder

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CC/C4CC09308A

Reference82 articles.

1. Asymmetric Organocatalytic Domino Reactions

2. Asymmetric Enamine Catalysis

3. The advent and development of organocatalysis

4. Asymmetric Organocatalytic Cyclization and Cycloaddition Reactions

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