Polysarcosine functionalised cationic polyesters efficiently deliver self-amplifying mRNA-Reference-Cited by-同舟云学术

Polysarcosine functionalised cationic polyesters efficiently deliver self-amplifying mRNA

Published:2024 Issue:18 Volume:15 Page:1862-1876
ISSN:1759-9954
Container-title:Polymer Chemistry
language:en
Short-container-title:Polym. Chem.

Author:

Bayraktutan Hulya¹^ORCID,Kopiasz Rafał J.¹²^ORCID,Elsherbeny Amr¹^ORCID,Martinez Espuga Magda³,Gumus Nurcan¹^ORCID,Oz Umut Can¹⁴^ORCID,Polra Krunal⁵,McKay Paul F.⁵^ORCID,Shattock Robin J.⁵,Ordóñez-Morán Paloma⁶,Mata Alvaro³⁷^ORCID,Alexander Cameron¹^ORCID,Gurnani Pratik⁸^ORCID

Affiliation:

1. Division of Molecular Therapeutics and Formulation, Boots Science Building, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK

2. Warsaw University of Technology, Faculty of Chemistry, Noakowskiego 3 St., 00-664, Warsaw, Poland

3. Division of Regenerative Medicine and Cell Therapies, BioDiscovery Institute, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK

4. Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, Ankara, 06560, Türkiye

5. Department of Infectious Diseases, Section of Immunology of Infection, Imperial College London, Norfolk Place, London, W21PG, UK

6. Centre for Cancer Sciences, BioDiscovery Institute, Translational Medical Sciences Unit, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK

7. Department of Chemical and Environmental Engineering, University of Nottingham, Nottingham, NG7 2RD, UK

8. UCL School of Pharmacy, University College London, 29-39 Brunswick Square, Bloomsbury, London, WC1N 1AX, UK

Abstract

In this work we demonstrate the endcapping of a poly(beta-amino ester) of polysarcosine, a widely established PEG-alternative, and show its ability as a non-viral vector for self-amplifying mRNA.

Funder

Türkiye Bilimsel ve Teknolojik Araştirma Kurumu

Wellcome Leap

Royal Society

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/PY/D4PY00064A

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