Substituted pyrrolyl-cyanopyridines on the platform of acylethynylpyrroles <i>via</i> their 1 : 2 annulation with acetonitrile under the action of lithium metal-Reference-Cited by-同舟云学术

Substituted pyrrolyl-cyanopyridines on the platform of acylethynylpyrroles via their 1 : 2 annulation with acetonitrile under the action of lithium metal

Published:2022 Issue:27 Volume:46 Page:13149-13155
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Tomilin Denis N.¹,Sobenina Lyubov N.¹,Saliy Ivan V.¹^ORCID,Ushakov Igor A.¹,Belogolova Aleksandra M.¹,Trofimov Boris A.¹^ORCID

Affiliation:

1. A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Science, 1 Favorsky Str., 664033 Irkutsk, Russia

Abstract

A facile one-pot synthesis of 2-(pyrrolyl)-4-aryl(hetaryl)-5-cyano-6-methylpyridines in 63–87% yield via the cyclization of available acylethynylpyrroles with two molecules of acetonitrile under the action of lithium metal at room temperature has been developed.

Funder

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D2NJ02011D

Reference32 articles.

1. Pyrroles and other heterocycles as inhibitors of P38 kinase

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