Synthesis and evaluation of anticancer activity of new 9-acridinyl amino acid derivatives-Reference-Cited by-同舟云学术

Synthesis and evaluation of anticancer activity of new 9-acridinyl amino acid derivatives

Published:2020 Issue:3 Volume:11 Page:378-386
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Rupar Jelena¹²³⁴⁵,Dobričić Vladimir¹²³⁴,Grahovac Jelena⁶⁷⁸⁴,Radulović Siniša⁶⁷⁸⁴,Skok Žiga⁹¹⁰¹¹¹²,Ilaš Janez⁹¹⁰¹¹¹²^ORCID,Aleksić Mara⁵²³⁴,Brborić Jasmina¹²³⁴,Čudina Olivera¹²³⁴

Affiliation:

1. Department of Pharmaceutical Chemistry

2. University of Belgrade – Faculty of Pharmacy

3. 11000 Belgrade

4. Serbia

5. Department of Physical Chemistry and Instrumental Methods

6. Department of Experimental Oncology

7. Institute for Oncology and Radiology of Serbia

8. Belgrade

9. Chair of Pharmaceutical Chemistry

10. University of Ljubljana, Faculty of Pharmacy

11. SI-1000 Ljubljana

12. Slovenia

Abstract

Compounds 6, 7, 8 and 9 exhibit lower or similar IC₅₀ values compared to amsacrine and showed a lack of toxicity towards unstimulated normal human leucocytes.

Funder

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/C9MD00597H

Reference31 articles.

1. Tuning of Intercalation and Electron-Transfer Processes between DNA and Acridinium Derivatives through Steric Effects

2. Acridine/acridone: a simple scaffold with a wide range of application in oncology

3. Novel synthetic acridine derivatives as potent DNA-binding and apoptosis-inducing antitumor agents

4. New series of acridines and phenanthrolines: synthesis and characterization

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