Chemical synthesis in competition with global genome mining and heterologous expression for the preparation of dimeric tryptophan-derived 2,5-dioxopiperazines-Reference-Cited by-同舟云学术

Chemical synthesis in competition with global genome mining and heterologous expression for the preparation of dimeric tryptophan-derived 2,5-dioxopiperazines

Published:2022 Issue:6 Volume:39 Page:1172-1225
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

García-Domínguez Patricia¹^ORCID,Areal Andrea¹^ORCID,Alvarez Rosana¹^ORCID,de Lera Angel R.¹

Affiliation:

1. CINBIO and Universidade de Vigo, 36310 Vigo, Spain

Abstract

Natural products chemists addressing global genome mining and heterologous expression, purification and structural determination, and the synthetic campaigns conspire to generate dimeric tryptophan-derived dioxopiperazines.

Funder

Ministerio de Economía y Competitividad

Xunta de Galicia

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NP/D2NP00006G

Reference163 articles.

1. The expanding spectrum of diketopiperazine natural product biosynthetic pathways containing cyclodipeptide synthases

2. Modifications of diketopiperazines assembled by cyclodipeptide synthases with cytochrome P450 enzymes