NMR reveals the metabolic changes induced by auranofin in A2780 cancer cells: evidence for glutathione dysregulation-Reference-Cited by-同舟云学术

NMR reveals the metabolic changes induced by auranofin in A2780 cancer cells: evidence for glutathione dysregulation

Published:2021 Issue:18 Volume:50 Page:6349-6355
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Ghini Veronica¹²³⁴⁵^ORCID,Senzacqua Tommaso¹²³⁴⁵,Massai Lara⁶²³⁴⁵^ORCID,Gamberi Tania⁷²⁴⁵^ORCID,Messori Luigi⁶²³⁴⁵^ORCID,Turano Paola¹²³⁴⁵^ORCID

Affiliation:

1. Center of Magnetic Resonance

2. University of Florence

3. Sesto Fiorentino

4. Firenze

5. Italy

6. Department of Chemistry

7. Department of Experimental and Clinical Biomedical Sciences

Abstract

NMR-based metabolomics is used to characterize the metabolic phenotype of auranofin treatment in A2780 ovarian cancer cells. The most distinctive trait is an early and evident increase of intracellular GSH, a key molecule in cell redox metabolism.

Funder

Ente Cassa di Risparmio di Firenze

Associazione Italiana per la Ricerca sul Cancro

Beneficentia Stiftung

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/DT/D1DT00750E

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