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Microfluidic isolation of platelet-covered circulating tumor cells

  • Published:2017 Issue:20 Volume:17 Page:3498-3503
  • ISSN:1473-0197
  • Container-title:Lab on a Chip
  • language:en
  • Short-container-title:Lab Chip

Author:

Jiang Xiaocheng12345,Wong Keith H. K.12345ORCID,Khankhel Aimal H.12345,Zeinali Mahnaz12345,Reategui Eduardo12345,Phillips Matthew J.12345ORCID,Luo Xi6734,Aceto Nicola67348,Fachin Fabio1234,Hoang Anh N.12345,Kim Wooseok12345,Jensen Annie E.12345,Sequist Lecia V.67348,Maheswaran Shyamala59734,Haber Daniel A.67348,Stott Shannon L.12346,Toner Mehmet12345

Affiliation:

1. Center for Engineering in Medicine

2. Massachusetts General Hospital & Harvard Medical School

3. Boston

4. USA

5. Department of Surgery

6. Massachusetts General Hospital Cancer Center

7. Harvard Medical School

8. Department of Medicine

9. Massachusetts General Hospital

Abstract

A new CTC isolation approach uncovers special populations of platelet-coated CTCs and CTC-leukocyte clusters in cancer patients.

Funder

National Institutes of Health

National Institute of Biomedical Imaging and Bioengineering

American Cancer Society

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Reference37 articles.

1. Trousseau's syndrome: multiple definitions and multiple mechanisms

2. T. Billroth , Lectures on surgical pathology and therapeutics: a handbook for students and practitioners, The New Syndenham Society, London, 1878

3. Platelets and cancer

4. Deadly allies: the fatal interplay between platelets and metastasizing cancer cells

5. Contribution of platelets to tumour metastasis

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