Dual effect of molecular mobility and functional groups of polyrotaxane surfaces on the fate of mesenchymal stem cells

Author:

Sekiya-Aoyama Ruriko12345ORCID,Arisaka Yoshinori12345ORCID,Hakariya Masahiro67385,Masuda Hiroki97385ORCID,Iwata Takanori67385,Yoda Tetsuya97385,Yui Nobuhiko12345ORCID

Affiliation:

1. Department of Organic Biomaterials

2. Institute of Biomaterials and Bioengineering

3. Tokyo Medical and Dental University (TMDU)

4. Chiyoda

5. Japan

6. Department of Periodontology

7. Graduate School of Medical and Dental Sciences

8. Bunkyo

9. Department of Maxillofacial Surgery

Abstract

Mesenchymal stem cells on polyrotaxane surfaces underwent enhanced osteoblast and adipocyte differentiation. Two independent parameters, high molecular mobility and negative charge on the surfaces, may not offset the effect to promote both differentiation.

Funder

Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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