Discovery of small-molecule inhibitors targeting the ribosomal peptidyl transferase center (PTC) of M. tuberculosis-Reference-Cited by-同舟云学术

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Discovery of small-molecule inhibitors targeting the ribosomal peptidyl transferase center (PTC) of M. tuberculosis

Published:2019 Issue:38 Volume:10 Page:8764-8767
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Tam Benjamin¹²³⁴,Sherf Dror¹²³⁴,Cohen Shira¹²³⁴,Eisdorfer Sarah Adi¹²³⁴,Perez Moshe⁵⁶⁷⁸,Soffer Adam⁹²⁴,Vilenchik Dan⁹²⁴,Akabayov Sabine Ruth⁵⁶⁷⁸,Wagner Gerhard¹⁰¹¹¹²¹³,Akabayov Barak¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. Ben-Gurion University of the Negev

3. Beer-Sheva

4. Israel

5. Department of Structural Biology

6. Weizmann Institute of Science

7. Rehovot

8. Israell

9. School of Computer and Electrical Engineering

10. Department of Biological Chemistry and Molecular Pharmacology

11. Harvard Medical School

12. Boston

13. USA

Abstract

A fast, accurate, and cost-effective design of small-molecule inhibitors that target RNA using a combined NMR-fragment-based and virtual screening.

Funder

United States-Israel Binational Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC02520K

Reference22 articles.

1. ZINC − A Free Database of Commercially Available Compounds for Virtual Screening

2. Automated docking of flexible ligands: Applications of autodock

3. Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus

4. Elongation Arrest by SecM via a Cascade of Ribosomal RNA Rearrangements

5. The Ribosomal Peptidyl Transferase

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4. Recent trends in RNA informatics: a review of machine learning and deep learning for RNA secondary structure prediction and RNA drug discovery;Briefings in Bioinformatics;2023-05-25

5. Fragment-Based Approaches to Identify RNA Binders;Journal of Medicinal Chemistry;2023-05-15

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