A new, substituted palladacycle for ppm level Pd-catalyzed Suzuki–Miyaura cross couplings in water-Reference-Cited by-同舟云学术

A new, substituted palladacycle for ppm level Pd-catalyzed Suzuki–Miyaura cross couplings in water

Published:2019 Issue:38 Volume:10 Page:8825-8831
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Takale Balaram S.¹²³⁴^ORCID,Thakore Ruchita R.¹²³⁴,Handa Sachin⁵⁶⁷⁴^ORCID,Gallou Fabrice⁸⁹¹⁰^ORCID,Reilly John¹¹¹²⁴,Lipshutz Bruce H.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry

2. University of California

3. Santa Barbara

4. USA

5. Department of Chemistry

6. University of Louisville

7. Louisville

8. Novartis Pharma AG

9. Basel

10. Switzerland

11. Novartis Institute for Medical Research

12. Cambridge

Abstract

A newly engineered palladacycle that contains substituents on the biphenyl rings along with the ligand HandaPhos is especially well-matched to an aqueous micellar medium, enabling valued Suzuki–Miyaura couplings to be run not only in water under mild conditions, but at 300 ppm of Pd catalyst.

Funder

Novartis

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC02528F

Reference36 articles.

1. 2-Aminobiphenyl Palladacycles: The “Most Powerful” Precatalysts in C–C and C–Heteroatom Cross-Couplings

2. A New Palladium Precatalyst Allows for the Fast Suzuki−Miyaura Coupling Reactions of Unstable Polyfluorophenyl and 2-Heteroaryl Boronic Acids

3. Design and preparation of new palladium precatalysts for C–C and C–N cross-coupling reactions