C-terminal tail insertion of Bcl-xL in membrane occurs via partial unfolding and refolding cycle associating microsolvation-Reference-Cited by-同舟云学术

C-terminal tail insertion of Bcl-xL in membrane occurs via partial unfolding and refolding cycle associating microsolvation

Published:2016 Issue:34 Volume:18 Page:24095-24105
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Maity Atanu¹²³⁴⁵,Sinha Souvik¹²³⁴⁵,Ganguly Debabani⁶⁷⁸⁵,Ghosh Dastidar Shubhra¹²³⁴⁵

Affiliation:

1. Bioinformatics Centre

2. Bose Institute

3. P-1/12 CIT Scheme VII M

4. Kolkata 700054

5. India

6. Department of Chemistry

7. Indian Institute of Engineering Science and Technology

8. Howrah-711103

Abstract

Insertion of the Bcl-x_L C-terminal into the mitochondrial outer membrane is found to be guided by the partial unfolding–refolding cycle, assisted by micro-solvation.

Funder

University Grants Committee

Council for Scientific and Industrial Research

Department of Biotechnology , Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CP/C6CP02468H

Reference42 articles.

1. BCL-2 family members and the mitochondria in apoptosis

2. The Bcl-2 Protein Family: Arbiters of Cell Survival

3. Characterization of the signal that directs Bcl-xL, but not Bcl-2, to the mitochondrial outer membrane

4. Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

5. Bax Exists in a Dynamic Equilibrium between the Cytosol and Mitochondria to Control Apoptotic Priming

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