Synthesis, cytotoxic activity, ADMET and molecular docking study of quinoline-based hybrid compounds of 1,5-benzothiazepines-Reference-Cited by-同舟云学术

Synthesis, cytotoxic activity, ADMET and molecular docking study of quinoline-based hybrid compounds of 1,5-benzothiazepines

Published:2020 Issue:47 Volume:44 Page:20715-20725
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Ngoc Toan Duong¹²³¹⁴,Thanh Nguyen Dinh¹⁴⁵³^ORCID,Truong Mai Xuan¹²³,Nghia Bang Duong¹⁶⁷⁸³,Thanh Nga Mai¹²³,Thi Thu Huong Nguyen¹⁴⁵³

Affiliation:

1. Faculty of Chemistry

2. TNU University of Education (Thai Nguyen University)

3. Vietnam

4. VNU University of Science (Vietnam National University, Ha Noi)

5. Ha Noi

6. TNU University of Science (Thai Nguyen University)

7. Tan Thinh Ward

8. Thai Nguyen City

Abstract

Some α,β-unsaturated ketones 4a–g of 3-acetyl-4-hydroxyquinolin-2(1H)-one were prepared and converted into a series of new hybrid compounds, quinoline-benzothiazepine 6a–g. Compounds 6d and 6g had the best activity against HepG2 and KB cell lines.

Funder

Bộ Giáo dục và Ðào tạo

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NJ/D0NJ04295A

Reference48 articles.

1. Benzo[1,5]thiazepine: Synthesis, Reactions, Spectroscopy, and Applications

2. Benzothiazepines: chemistry of a privileged scaffold

3. 1,5-Benzothiazepine, a versatile pharmacophore: A review