Biocompatible conjugated fluorenylporphyrins for two-photon photodynamic therapy and fluorescence imaging

Author:

Shi Limiao12345,Nguyen Christophe678910ORCID,Daurat Morgane678910ORCID,Dhieb Abdelhamid Chiheb12345,Smirani Wajda1112131415,Blanchard-Desce Mireille16171810ORCID,Gary-Bobo Magali678910ORCID,Mongin Olivier12345ORCID,Paul-Roth Christine12345ORCID,Paul Frédéric12345ORCID

Affiliation:

1. Univ Rennes

2. INSA Rennes

3. CNRS

4. ISCR (Institut des Sciences Chimiques de Rennes) – UMR 6226

5. F-35000 Rennes

6. Institut des Biomolécules Max Mousseron

7. UMR 5247

8. Université de Montpellier

9. 34093 Montpellier Cedex 05

10. France

11. Laboratoire de Chimie des Matériaux

12. Faculté des Sciences de Bizerte

13. Université de Carthage

14. 7021 Zarzouna

15. Tunisia

16. Univ. Bordeaux

17. Institut des Sciences Moléculaires (CNRS UMR 5255)

18. 33405 Talence

Abstract

Three new biocompatible porphyrin-based oxygen photosensitisers were tested in vitro on breast cancer cells via 2P-PDT: one of them, 66 times more active than H2TPP, gave quite promising results for theranostic applications.

Funder

Ligue Contre le Cancer

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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