Design and chemical synthesis of eukaryotic chromosomes

Author:

Xie Ze-Xiong12345ORCID,Liu Duo12345ORCID,Li Bing-Zhi12345ORCID,Zhao Meng12345ORCID,Zeng Bo-Xuan12345ORCID,Wu Yi12345ORCID,Shen Yue675ORCID,Lin Tao675ORCID,Yang Ping8910ORCID,Dai Junbiao11121314ORCID,Cai Yizhi15161718ORCID,Yang Huanming6751920ORCID,Yuan Ying-Jin12345ORCID

Affiliation:

1. Key Laboratory of Systems Bioengineering (Ministry of Education)

2. School of Chemical Engineering and Technology

3. Tianjin University

4. Tianjin 300072

5. P. R. China

6. BGI-Shenzhen

7. Shenzhen 518083

8. Synbio Technologies

9. Monmouth Junction

10. USA

11. Center for Synthetic Biology Engineering Research, Shenzhen Institutes of Advanced Technology

12. Chinese Academy of Sciences

13. Shenzhen 518055

14. China

15. Manchester Institute of Biotechnology

16. University of Manchester

17. Manchester

18. UK

19. James D. Watson Institute of Genome Sciences

20. Hangzhou 310058

Abstract

We reviewed the design, building, testing and debugging technologies and methodologies for synthesizing designer eukaryotic chromosomes and forecasted their applications.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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