Flavin-mediated photoactivation of Pt(<scp>iv</scp>) anticancer complexes: computational insights on the catalytic mechanism-Reference-Cited by-同舟云学术

Flavin-mediated photoactivation of Pt(iv) anticancer complexes: computational insights on the catalytic mechanism

Published:2022 Issue:9 Volume:24 Page:5323-5329
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Scoditti Stefano¹^ORCID,Dabbish Eslam¹,Pieslinger German E.²^ORCID,Rezabal Elixabete³⁴^ORCID,Lopez Xabier³⁴^ORCID,Sicilia Emilia¹^ORCID,Salassa Luca³⁴⁵^ORCID

Affiliation:

1. Department of Chemistry and Chemical Technologies, Università della Calabria, Arcavacata di Rende (CS), 87036, Italy

2. CONICET – Universidad de Buenos Aires, Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Buenos Aires, Argentina

3. Donostia International Physics Center, Paseo Manuel de Lardizabal 4, Donostia, 20018, Spain

4. Polimero eta Material Aurreratuak: Fisika, Kimika eta Teknologia, Kimika Fakultatea, Euskal Herriko Unibertsitatea UPV/EHU, Paseo Manuel de Lardizabal 3, Donostia, 20018, Spain

5. Ikerbasque, Basque Foundation for Science, Bilbao, 48011, Spain

Abstract

DFT studies reveal why riboflavin is an efficient photocatalyst for the activation through reduction of Pt(iv) anticancer prodrugs.

Funder

Ministerio de Ciencia e Innovación

Diputación Foral de Gipuzkoa

Ministerio de Economía y Competitividad

Agencia Estatal de Investigación

Eusko Jaurlaritza

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CP/D1CP05507K

Reference36 articles.

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4. Photoexcitation of flavoenzymes enables a stereoselective radical cyclization

5. Asymmetric redox-neutral radical cyclization catalysed by flavin-dependent ‘ene’-reductases

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