Urethral reconstruction using an amphiphilic tissue-engineered autologous polyurethane nanofiber scaffold with rapid vascularization function

Author:

Niu Yuqing12345ORCID,Liu Guochang63457,Chen Chuangbi89101112ORCID,Fu Ming63457ORCID,Fu Wen63457,Zhao Zhang63457,Xia Huimin12345ORCID,Stadler Florian J.89101112ORCID

Affiliation:

1. Department of Pediatric Surgery

2. Guangzhou Institute of Pediatrics

3. Guangzhou Women and Children's Medical Center

4. Guangzhou Medical University

5. Guangzhou 510623

6. Department of Pediatric Urology

7. China

8. Nanshan District Key Lab for Biopolymers and Safety Evaluation

9. Shenzhen Key Laboratory of Polymer Science and Technology

10. Guangdong Research Center for Interfacial Engineering of Functional Materials

11. College of Materials Science and Engineering

12. Shenzhen University

Abstract

We report the efficient application of a well-layered tubular amphiphilic nanofiber of a polyurethane copolymer (PU-ran) for the regulation the phenotypic expression of epithelial cells (ECs) and smooth muscle cells (SMCs) for vascularized urethral reconstruction.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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