Functionalized resorcinarenes effectively disrupt the aggregation of αA66-80 crystallin peptide related to cataracts-Reference-Cited by-同舟云学术

Functionalized resorcinarenes effectively disrupt the aggregation of αA66-80 crystallin peptide related to cataracts

Published:2021 Issue:12 Volume:12 Page:2022-2030
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Twum Kwaku¹^ORCID,Bhattacharjee Avik²^ORCID,Laryea Erving T.¹^ORCID,Esposto Josephine³^ORCID,Omolloh George²^ORCID,Mortensen Shaelyn³,Jaradi Maya¹^ORCID,Stock Naomi L.⁴^ORCID,Schileru Nicholas¹⁵,Elias Bianca¹,Pszenica Elan¹,McCormick Theresa M.²^ORCID,Martic Sanela³⁴^ORCID,Beyeh Ngong Kodiah¹^ORCID

Affiliation:

1. Department of Chemistry, Oakland University, 146 Library Drive, Rochester, MI 48309-4479, USA

2. Department of Chemistry, Portland State University, 1710 SW 10th Ave, Portland, OR 97201, USA

3. Department of Forensic Science and Environmental and Life Sciences Program, Trent University, ON, K9 L0G2, Canada

4. Water Quality Centre, Trent University, ON, K9L 0G2, Canada

5. Department of Osteopathic Medicine, Midwestern University, 555 31st St., Downers Grove, IL 60515, USA

Abstract

Ionic resorcinarenes successfully disrupt the aggregation of αA66-80 crystallin peptide related to cataracts. The results show functionalized resorcinarenes as potential agents to reverse the aggregation of α-crystallin dominant in eye cataracts.

Funder

Oakland University

Trent University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00294E

Reference40 articles.

1. Genetics of crystallins: Cataract and beyond

2. A new dawn for cataracts