Structure-based virtual screening and ADME/T-based prediction analysis for the discovery of novel antifungal CYP51 inhibitors-Reference-Cited by-同舟云学术

Structure-based virtual screening and ADME/T-based prediction analysis for the discovery of novel antifungal CYP51 inhibitors

Published:2018 Issue:7 Volume:9 Page:1178-1187
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Sun Bin¹²³⁴⁵^ORCID,Zhang Hong⁶⁷⁵,Liu Min⁸⁹⁷⁵,Hou Zhuang¹⁰¹¹¹²¹³⁵,Liu Xinyong¹²³⁴⁵

Affiliation:

1. Department of Medicinal Chemistry

2. School of Pharmaceutical Sciences

3. Shandong University

4. Jinan 250012

5. PR China

6. Liaocheng People's Hospital

7. Liaocheng 252000

8. Institute of BioPharmaceutical Research

9. Liaocheng University

10. Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education

11. School of Pharmaceutical Engineering

12. Shenyang Pharmaceutical University

13. Shenyang 110016

Abstract

With the increasing incidence of pathogenic fungi and drug-resistant fungi in clinic, it has become very important to develop the novel rate-limiting enzyme 14α-demethylase (CYP51) as an antifungal inhibitor.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MD/C8MD00230D

Reference25 articles.

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