Targeting of the Leishmania mexicana cysteine protease CPB2.8ΔCTE by decorated fused benzo[b]thiophene scaffold-Reference-Cited by-同舟云学术

Targeting of the Leishmania mexicana cysteine protease CPB2.8ΔCTE by decorated fused benzo[b]thiophene scaffold

Published:2016 Issue:36 Volume:6 Page:30628-30635
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Scala A.¹²³⁴⁵,Micale N.¹²³⁴⁵,Piperno A.¹²³⁴⁵,Rescifina A.⁶⁷⁸⁹^ORCID,Schirmeister T.¹⁰¹¹¹²¹³,Kesselring J.¹⁰¹¹¹²¹³,Grassi G.¹²³⁴⁵

Affiliation:

1. Dipartimento di Scienze Chimiche

2. Biologiche

3. Farmaceutiche ed Ambientali

4. Università di Messina

5. 98166 Messina

6. Dipartimento di Scienze del Farmaco

7. Università degli Studi di Catania

8. 95125 Catania

9. Italy

10. Institute of Pharmacy and Biochemistry

11. University of Mainz

12. D 55099 Mainz

13. Germany

Abstract

A potent and highly selective anhydride-based inhibitor ofLeishmania mexicanacysteine protease CPB2.8 (IC₅₀= 3.7 μM) was investigated by inhibition assays, NMR biomimetic experiments and docking studies.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA05557E

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