Antibody-functionalized theranostic protein nanoparticles for the synergistic deep red fluorescence imaging and multimodal therapy of ovarian cancer

Author:

Borlan Raluca12,Focsan Monica2ORCID,Perde-Schrepler Maria3,Soritau Olga3,Campu Andreea2,Gaina Luiza4,Pall Emoke5,Pop Bogdan67,Baldasici Oana8,Gherman Claudia9,Stoia Daria2,Maniu Dana12ORCID,Astilean Simion12ORCID

Affiliation:

1. Biomolecular Physics Department, Faculty of Physics, Babes-Bolyai University, Cluj-Napoca, Cluj, Romania

2. Nanobiophotonics and Laser Microspectroscopy Centre, Interdisciplinary Research Institute on Bio-Nano-Sciences, Babes-Bolyai University, Cluj-Napoca, Cluj, Romania

3. Department of Radiobiology and Tumor Biology, Oncology Institute Prof. Dr. Ion Chiricuta, Cluj-Napoca, Cluj, Romania

4. The Research Centre on Fundamental and Applied Heterochemistry, Department of Chemistry, Faculty of Chemistry and Chemical Engineering, Babes-Bolyai University, Cluj-Napoca, Cluj, Romania

5. Department of Infectious Diseases, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Cluj, Romania

6. Department of Pathology, Oncology Institute Prof. Dr. Ion Chiricuta, Cluj-Napoca, Cluj, Romania

7. Department of Pathology, University of Medicine and Pharmacy Iuliu Haţieganu, Cluj-Napoca, Cluj, Romania

8. Department of Functional Genomics, Proteomics and Experimental Pathology, Oncology Institute Prof. Dr. Ion Chiricuta, Cluj-Napoca, Cluj, Romania

9. Department of Functional Genomics, Proteomics and Experimental Pathology, Oncology Institute Prof. Dr Ion Chiricuta, Cluj-Napoca, Cluj, Romania

Abstract

This work presents novel phototheranostic protein nanoagents loaded with a newly synthesized deep red dye, revealing fluorescence imaging, photothermal and photodynamic features simultaneously upon targeted internalization within ovarian cancer cells.

Funder

Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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