Palladium-catalyzed native α-amino acid derivative-directed arylation/oxidation of benzylic C–H bonds: synthesis of 5-aryl-1,4-benzodiazepin-2-ones-Reference-Cited by-同舟云学术

Palladium-catalyzed native α-amino acid derivative-directed arylation/oxidation of benzylic C–H bonds: synthesis of 5-aryl-1,4-benzodiazepin-2-ones

Published:2022 Issue:69 Volume:58 Page:9638-9641
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Jiang Fengxuan¹²,Xu Menghua³,Bei Wenfeng¹,Cheng Kai¹^ORCID,Huang Lehao²^ORCID

Affiliation:

1. Key Laboratory of Alternative Technologies for Fine Chemicals Process, Institute of Applied Chemistry, Shaoxing University, Shaoxing, Zhejiang Province 312000, People's Republic of China

2. School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang Province 325035, People's Republic of China

3. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, P. R. China

Abstract

A Pd-catalyzed, native α-amino acid derivative-directed benzylic C–H bond arylation/oxidation with aryl iodides was developed. The bifunctional products could be readily converted into 5-aryl-1,4-benzodiazepin-2-ones.

Funder

Natural Science Foundation of Zhejiang Province

Wenzhou Medical University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC03266J

Reference35 articles.

1. 1,4-benzodiazepin-2-ones in medicinal chemistry

2. Privileged Structures: A Useful Concept for the Rational Design of New Lead Drug Candidates

3. The benzodiazepine story

4. Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists

5. High affinity, bioavailable 3-Amino-1,4-benzodiazepine-Based γ-Secretase inhibitors

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