Discovery of mitochondrion-targeting copper(<scp>ii</scp>)-plumbagin and -bipyridine complexes as chemodynamic therapy agents with enhanced antitumor activity-Reference-Cited by-同舟云学术

Discovery of mitochondrion-targeting copper(ii)-plumbagin and -bipyridine complexes as chemodynamic therapy agents with enhanced antitumor activity

Published:2024 Issue:7 Volume:53 Page:3244-3253
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Zhang Hai-Qun¹,Lu Xing²,Wu Jiang-Lun¹,Ou Mei-Quan¹,Chen Nan-Feng¹,Liang Hong¹,Chen Zhen-Feng¹^ORCID

Affiliation:

1. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China

2. Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, The Affiliated Hospital of Guilin Medical University, Guilin 541001, China

Abstract

Four complexes (Cu1–Cu4) that consume glutathione (GSH) were synthesized as mitochondrion-targeting antitumor agents with enhanced chemodynamic therapy (CDT),exhibiting strong anti-tumor activity both in vitro and in vivo.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangxi Zhuang Autonomous Region

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/DT/D3DT03806H

Reference57 articles.

1. Mitochondrial Redox Hubs as Promising Targets for Anticancer Therapy

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3. Mito‐Bomb: Targeting Mitochondria for Cancer Therapy

4. Smart Design of Nanomaterials for Mitochondria‐Targeted Nanotherapeutics

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