RNA-targeting low-molecular-weight fluorophores for nucleoli staining: synthesis, in silico modelling and cellular imaging

Author:

Kurutos Atanas1234ORCID,Nikodinovic-Runic Jasmina5678,Veselinovic Aleksandar91011128ORCID,Veselinović Jovana B.5678,Kamounah Fadhil S.9131415,Ilic-Tomic Tatjana5678

Affiliation:

1. Institute of Organic Chemistry with Centre of Phytochemistry

2. Bulgarian Academy of Sciences

3. 1113 Sofia

4. Bulgaria

5. Institute of Molecular Genetics and Genetic Engineering

6. University of Belgrade

7. 11000 Belgrade

8. Serbia

9. Department of Chemistry

10. Faculty of Medicine

11. University of Niš

12. 18108 Niš

13. University of Copenhagen

14. DK-2100 Copenhagen

15. Denmark

Abstract

Herein we present our work on the synthesis, investigation of the photophysical properties, interactions with nucleic acids, molecular docking, and imaging application of three carbocyanine dyes.

Funder

Bulgarian National Science Fund

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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