Covalent labeling of a chromatin reader domain using proximity-reactive cyclic peptides-Reference-Cited by-同舟云学术

Covalent labeling of a chromatin reader domain using proximity-reactive cyclic peptides

Published:2022 Issue:22 Volume:13 Page:6599-6609
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zhang Meng Yao¹,Yang Hyunjun²^ORCID,Ortiz Gloria¹,Trnka Michael J.²,Petronikolou Nektaria¹,Burlingame Alma L.²,DeGrado William F.²,Fujimori Danica Galonić¹²³^ORCID

Affiliation:

1. Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94158, USA

2. Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94158, USA

3. Quantitative Biosciences Institute, University of California San Francisco, San Francisco, CA 94158, USA

Abstract

We describe the development of covalent cyclic peptide ligands which target a chromatin methylation reader domain using a proximity-reactive sulfonyl fluoride moiety.

Funder

National Cancer Institute

National Institutes of Health

BrightFocus Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC00555G

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