Conformationally strained trans-cyclooctene with improved stability and excellent reactivity in tetrazine ligation-Reference-Cited by-同舟云学术

Conformationally strained trans-cyclooctene with improved stability and excellent reactivity in tetrazine ligation

Published:2014 Issue:10 Volume:5 Page:3770-3776
ISSN:2041-6520
Container-title:Chem. Sci.
language:en
Short-container-title:Chem. Sci.

Author:

Darko Ampofo¹²³⁴,Wallace Stephen⁵⁶⁷,Dmitrenko Olga¹²³⁴,Machovina Melodie M.⁸⁹¹⁰,Mehl Ryan A.⁸⁹¹⁰,Chin Jason W.⁵⁶⁷,Fox Joseph M.¹²³⁴

Affiliation:

1. Brown Laboratory

2. Department of Chemistry & Biochemistry

3. University of Delaware

4. Newark, USA

5. Medical Research Council Laboratory of Molecular Biology

6. Cambridge Biomedical Campus

7. Cambridge CB2 0QH, UK

8. Department of Biochemistry and Biophysics

9. Oregon State University

10. Corvallis, USA

Abstract

Computation has guided the design of conformationally-strained dioxolane-fusedtrans-cyclooctene (d-TCO) derivatives that display excellent reactivity in the tetrazine ligation.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/SC/C4SC01348D

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