A novel fluorescent digitonin derivative for non-invasive skin cholesterol detection: potential application in atherosclerosis screening

Author:

Ni Jingshu12ORCID,Liu Yong123,Hong Haiou4,Kong Xiangyong4,Han Yongsheng4,Zhang Lei5,Zhang Yang12,Zhang Yuanzhi13,Hua Changyi1,Wang Quanfu1,Wang Xia1,Huang Yao13,YiKun Wang13,Meili Dong13ORCID

Affiliation:

1. Anhui Provincial Engineering Technology Research Center for Biomedical Optical Instrument, Anhui Provincial Engineering Laboratory for Medical Optical Diagnosis &Treatment Technology and Instrument, Anhui Institute of Optics and Fine Mechanics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China

2. University of Science and Technology of China, Hefei, 230026, China

3. Wanjiang Center for Development of Emerging Industrial Technology, Tongling, 244000, China

4. The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China

5. Anhui Provincial Institute for Food and Drug Control, Hefei, 230051, China

Abstract

Digitonin was used to synthesise a fluorescence probe for the non-invasive detection of skin cholesterol. This non-invasive skin cholesterol method may be used as a risk assessment tool for atherosclerosis screening in a large population.

Funder

Anhui Provincial Department of Science and Technology

Chinese Academy of Sciences

Natural Science Foundation of Anhui Province

Anhui Provincial Key Research and Development Plan

Hefei Institutes of Physical Science, Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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