Single point mutations can potentially enhance infectivity of SARS-CoV-2 revealed by in silico affinity maturation and SPR assay-Reference-Cited by-同舟云学术

Single point mutations can potentially enhance infectivity of SARS-CoV-2 revealed by in silico affinity maturation and SPR assay

Published:2021 Issue:24 Volume:11 Page:14737-14745
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Xue Ting¹²³⁴⁵,Wu Weikun⁶⁷⁸,Guo Ning⁶⁷⁸,Wu Chengyong¹²³⁴⁵,Huang Jian⁶⁷⁸,Lai Lipeng⁶⁷⁸,Liu Hong¹²³⁴⁵,Li Yalun¹²³⁴⁵,Wang Tianyuan⁶⁷⁸,Wang Yuxi¹²³⁴⁵^ORCID

Affiliation:

1. Targeted Tracer Research and Development Laboratory

2. Precision Medicine Research Center

3. Department of Respiratory and Critical Care Medicine

4. West China Hospital

5. Sichuan University

6. XtalPi AI Research Center

7. Beijing 100083

8. P. R. China

Abstract

The RBD (receptor binding domain) of the SARS-CoV-2 virus S (spike) protein mediates viral cell attachment and serves as a promising target for therapeutics development.

Funder

China Postdoctoral Science Foundation

West China Hospital, Sichuan University

Department of Science and Technology of Sichuan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D1RA00426C

Reference22 articles.

1. A new coronavirus associated with human respiratory disease in China