Differentiability of cell types enhanced by detrending a non-homogeneous pattern in a line-illumination Raman microscope

Author:

Bhuiyan Abdul Halim12,Clément Jean-Emmanuel3,Ferdous Zannatul3,Mochizuki Kentaro4,Tabata Koji35,Taylor James Nicholas5,Kumamoto Yasuaki67ORCID,Harada Yoshinori4,Bocklitz Thomas8910ORCID,Fujita Katsumasa6711ORCID,Komatsuzaki Tamiki135712ORCID

Affiliation:

1. Graduate School of Chemical Sciences and Engineering, Materials Chemistry and Engineering Course, Hokkaido University, Kita 13, Nishi 8, Kita-ku, Sapporo, 060-8628, Hokkaido, Japan

2. Department of Mathematics, Bangladesh University of Engineering and Technology, Dhaka-1000, Bangladesh

3. Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Kita 21 Nishi 10, Kita-ku, Sapporo, 001-0021, Hokkaido, Japan

4. Department of Pathology and Cell Regulation, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo, Kyoto, 602-8566, Kyoto, Japan

5. Research Center of Mathematics for Social Creativity, Research Institute for Electronic Science, Hokkaido University, Kita 20 Nishi 10, Kita-ku, Sapporo, 001-0020, Hokkaido, Japan

6. Department of Applied Physics, Osaka University, 2-1 Yamadaoka, Suita, 565-0871, Osaka, Japan

7. Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Yamadaoka, Suita, 565-0871, Osaka, Japan

8. Leibniz Institute of Photonic Technology (Leibniz-IPHT), Albert-Einstein-Straße 9, 07745 Jena, Germany

9. Institute of Physical Chemistry and Abbe Center of Photonics (IPC/ACP), Friedrich-Schiller-University, Helmholtzweg 4, D-07743 Jena, Germany

10. Institute of Computer Science, Faculty of Mathematics, Physics & Computer Science, University Bayreuth, Universitaetsstraße 30, 95447 Bayreuth, Germany

11. Advanced Photonics and Biosensing Open Innovation Laboratory, AIST-Osaka University, Yamadaoka, Suita, 565-0871, Osaka, Japan

12. The Institute of Scientific and Industrial Research, Osaka University, Mihogaoka, Ibaraki, 8-1, Osaka, 567-0047, Japan

Abstract

A detrending algorithm for high-speed Raman imaging enhances the detection of cancer cells.

Funder

Japan Science and Technology Agency

Core Research for Evolutional Science and Technology

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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