1,5-Disubstituted tetrazoles as PD-1/PD-L1 antagonists-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

1,5-Disubstituted tetrazoles as PD-1/PD-L1 antagonists

Published:2024 Issue:4 Volume:15 Page:1210-1215
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

van der Straat Robin¹,Draijer Rosalie¹,Surmiak Ewa²^ORCID,Butera Roberto¹,Land Lennart¹,Magiera-Mularz Katarzyna²,Musielak Bogdan²,Plewka Jacek²^ORCID,Holak Tad A.²,Dömling Alexander¹³^ORCID

Affiliation:

1. Department of Drug Design, University of Groningen, 9713 AV Groningen, The Netherlands

2. Department of Organic Chemistry, Faculty of Chemistry, Jagiellonian University, 30-387 Kraków, Poland

3. Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry and Czech Advanced Technology and Research Institute, Palackȳ University in Olomouc, Olomouc, Czech Republic

Abstract

Utilizing a combination of structure-based design, MCR synthesis, biophysics, and protein crystallography to innovate a novel tetrazole scaffold targeting the PD-1/PD-L1 immune checkpoint protein complex.

Funder

Fundacja na rzecz Nauki Polskiej

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00746D

Reference31 articles.

1. Programmed Death-1: Therapeutic Success after More than 100 Years of Cancer Immunotherapy

2. Nivolumab success in untreated metastatic melanoma

3. Regulation and Function of the PD-L1 Checkpoint

4. Regulatory T-cell inhibition versus depletion: the right choice in cancer immunotherapy

5. Pembrolizumab versus Ipilimumab in Advanced Melanoma

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP