Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state-Reference-Cited by-同舟云学术

Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state

Published:2017 Issue:31 Volume:15 Page:6656-6667
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

van Haren Matthijs J.¹²³⁴⁵,Taig Rebecca¹²³⁴⁵,Kuppens Jilles¹²³⁴⁵,Sastre Toraño Javier¹²³⁴⁵,Moret Ed E.¹²³⁴⁵,Parsons Richard B.⁶⁷⁸⁹,Sartini Davide¹⁰¹¹¹²¹³,Emanuelli Monica¹⁰¹¹¹²¹³,Martin Nathaniel I.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Chemical Biology & Drug Discovery

2. Utrecht Institute for Pharmaceutical Sciences

3. Utrecht University

4. 3584 CG Utrecht

5. The Netherlands

6. Institute of Pharmaceutical Science

7. King's College London

8. London SE1 9NH

9. UK

10. Department of Clinical Sciences

11. Universitá Politecnica delle Marche

12. Ancona

13. Italy

Abstract

Inhibitors designed to simultaneously occupy the different substrate binding pockets of the NNMT active site reveal key structural features required for potent inhibition.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB01357D

Reference29 articles.

1. Identification of Nicotinamide N-Methyltransferase as a Novel Tumor Marker for Renal Clear Cell Carcinoma

2. Correction: The Endocytic Adaptor Eps15 Controls Marginal Zone B Cell Numbers

3. Nicotinamide N-methyltransferase in Non-small Cell Lung Cancer: Promising Results for Targeted Anti-cancer Therapy

4. NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink

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