Modular mixing of benzene-1,3,5-tricarboxamide supramolecular hydrogelators allows tunable biomimetic hydrogels for control of cell aggregation in 3D-Reference-Cited by-同舟云学术

Modular mixing of benzene-1,3,5-tricarboxamide supramolecular hydrogelators allows tunable biomimetic hydrogels for control of cell aggregation in 3D

Published:2022 Issue:17 Volume:10 Page:4740-4755
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Hafeez Shahzad¹^ORCID,Passanha Fiona R.²,Feliciano Antonio J.¹,Ruiter Floor A. A.¹²,Malheiro Afonso¹,Lafleur René P. M.³^ORCID,Matsumoto Nicholas M.³,van Blitterswijk Clemens¹,Moroni Lorenzo¹^ORCID,Wieringa Paul¹^ORCID,LaPointe Vanessa L. S.²^ORCID,Baker Matthew B.¹^ORCID

Affiliation:

1. Department of Complex Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands

2. Department of Cell Biology-Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands

3. Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands

Abstract

Dynamic hydrogels can allow cells to form complex multicellular aggregates. Herein, we show that the dynamics of the hydrogel environment can directly influence the speed and size of cellular aggregates formed by using a modularly tunable supramolecular hydrogel.

Funder

Ministerie van Onderwijs, Cultuur en Wetenschap

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D2BM00312K

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1. The design of reversible hydrogels to capture extracellular matrix dynamics