Lysosome passivation triggered by silver nanoparticles enhances subcellular-targeted drug therapy

Author:

Wang Xueqian12,Zhao Shulin12,Fang Guiqian12ORCID,Wang Ran32,Lyu Xinxing2,Shao Xintian42,Ling Peixue3,Meng CaiCai4,Chen Jia2,Mu Yanling1ORCID

Affiliation:

1. School of Pharmaceutical Sciences & Institute of Materia Medica, National Key Laboratory of Advanced Drug Delivery System, Medical Science and Technology Innovation Center, Key Laboratory for Biotechnology Drugs of National Health Commission, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, PR China

2. Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, PR China

3. Shandong Academy of Pharmaceutical Science, Key Laboratory of Biopharmaceuticals, Engineering Laboratory of Polysaccharide Drugs, National-Local Joint Engineering Laboratory of Polysaccharide Drugs, Jinan 250101, PR China

4. School of Life Sciences, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, PR China

Abstract

Lysosome passivation strategy for enhancing subcellular-targeted drug therapy.

Funder

Key Technology Research and Development Program of Shandong

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Publisher

Royal Society of Chemistry (RSC)

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