Synthesis of unsymmetrical urea derivatives via one-pot sequential three-component reactions of cyclic 2-diazo-1,3-diketones, carbodiimides, and 1,2-dihaloethanes-Reference-Cited by-同舟云学术

Synthesis of unsymmetrical urea derivatives via one-pot sequential three-component reactions of cyclic 2-diazo-1,3-diketones, carbodiimides, and 1,2-dihaloethanes

Published:2020 Issue:22 Volume:18 Page:4178-4182
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

He Xinwei¹²³⁴⁵^ORCID,Yang Cheng¹²³⁴⁵,Wu Yinsong¹²³⁴⁵,Xie Mengqing¹²³⁴⁵,Li Ruxue¹²³⁴⁵,Duan Jiahui¹²³⁴⁵,Shang Yongjia¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Functional Molecular Solids

2. Ministry of Education

3. Anhui Laboratory of Molecule-Based Materials (State Key Laboratory Cultivation Base)

4. College of Chemistry and Materials Science

5. Anhui Normal University

Abstract

An effective and operationally simple one-pot strategy has been developed for the synthesis of unsymmetrical urea derivatives via sequential three-component reactions of cyclic 2-dizao-1,3-diketones with carbodiimides and 1,2-dihaloethane.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Anhui Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB00683A

Reference85 articles.

1. UNSYMMETRICAL UREAS. SYNTHETIC METHODOLOGIES AND APPLICATION IN DRUG DESIGN

2. A Scaleable Synthesis of BAY 43-9006: A Potent Raf Kinase Inhibitor for the Treatment of Cancer